منابع مشابه
NSF and AMPA Receptors Get Physical
the vesicle expresses a specific membrane protein Department of Neurobiology (v-SNARE) that binds to a cognate receptor on the target Howard Hughes Medical Institute membrane (t-SNARE). For synaptic vesicle exocytosis, Massachusetts General Hospital the v-SNARE VAMP/synaptobrevin, an integral mem-and Harvard Medical School brane protein of the synaptic vesicle, interacts with the Boston, Massac...
متن کاملGating modes in AMPA receptors.
AMPA receptors are ligand-gated ion channels that show multiple conductance levels, indicating that gating of individual AMPA subunits is to some extent independent of the other subunits. To study AMPAR subunit interactions during activation gating, we recorded from single channels in the absence of channel block and desensitization and at negative and positive membrane potentials. In saturatin...
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Determining the precise subunit composition of AMPARs in situ has been an enduring challenge. In this issue of Neuron, Lu et al. make significant headway into this pesky problem by using a clever single-cell genetic knockout approach. In a Herculean effort, they provide the field with the completeness of a pie chart outlining the contribution of each AMPAR subunit to basal synaptic transmission...
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Tumor cells: a single signal to divide and conquer? etastatic tumor cells are dangerous because they not only proliferate but also migrate and invade other tissues. On page 817, Manes et al. reach the surprising conclusion that the cyclin-dependent kinase cdc2 regulates both of these activities. The work identifies a novel signaling pathway and points to a promising new strategy for targeting m...
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ژورنال
عنوان ژورنال: Nature
سال: 2009
ISSN: 0028-0836,1476-4687
DOI: 10.1038/458585a